Microtubule binding distinguishes dystrophin from utrophin.

  title={Microtubule binding distinguishes dystrophin from utrophin.},
  author={Joseph J. Belanto and Tara L. Mader and Michael D Eckhoff and Dana M. Strandjord and Glen B. Banks and Melissa K Gardner and Dawn A Lowe and James M. Ervasti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 15},
Dystrophin and utrophin are highly similar proteins that both link cortical actin filaments with a complex of sarcolemmal glycoproteins, yet localize to different subcellular domains within normal muscle cells. In mdx mice and Duchenne muscular dystrophy patients, dystrophin is lacking and utrophin is consequently up-regulated and redistributed to locations normally occupied by dystrophin. Transgenic overexpression of utrophin has been shown to significantly improve aspects of the disease… CONTINUE READING
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