Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma

@article{Jiang2016MicrotubuleassociatedP4,
  title={Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma},
  author={Y Jiang and Liang Shang and Z-Z Shi and T-T Zhang and Stephanie Ma and C-C Lu and Ye-wei Zhang and J Hao and Chen Shi and F Shi and Xiang-Xi Xu and Ying Cai and X-M Jia and Q Zhan and M-R Wang},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={4846-4856}
}
Cell invasion and migration significantly contribute to tumor metastasis. Microtubule-associated protein 4 (MAP4) protein is one member of microtubule-associate proteins family. It is responsible for stabilization of microtubules by modulation of microtubule dynamics. However, there is little information about the involvement of MAP4 in human cancer. Here we show that MAP4 serves as a regulator of invasion and migration in esophageal squamous cancer cells. By activating the ERK-c-Jun-vascular… CONTINUE READING

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