Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor.

  title={Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor.},
  author={Virginie Fontaine-Lenoir and B{\'e}atrice Chambraud and Arlette Fellous and Sebastien David and Yann Duchossoy and Etienne Emile Baulieu and Paul Robel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 12},
The neurosteroid pregnenolone (PREG) and its chemically synthesized analog 3beta-methoxypregnenolone (MePREG) bind to microtubule-associated protein 2 (MAP2) and stimulate the polymerization of microtubules. PREG, MePREG, and progesterone (PROG; the physiological immediate metabolite of PREG) significantly enhance neurite outgrowth of nerve growth factor… CONTINUE READING