Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.

@article{Martinez2011MicrotubuleassociatedP1,
  title={Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.},
  author={Jennifer Martinez and Johann Almendinger and Andrew Oberst and Rachel M Ness and Christopher P Dillon and Patrick O Fitzgerald and Michael O. Hengartner and Douglas R Green},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 42},
  pages={17396-401}
}
The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was identified wherein the autophagy machinery is recruited to pathogen-containing phagosomes, termed MAPLC3A (LC3)-associated phagocytosis (LAP), which results in optimal degradation of the phagocytosed cargo. Here, we describe the engagement of LAP upon uptake of apoptotic, necrotic, and RIPK3-dependent necrotic cells by macrophages. This… CONTINUE READING
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