Microtubule assembly dynamics: An attractive target for anticancer drugs

  title={Microtubule assembly dynamics: An attractive target for anticancer drugs},
  author={P. Singh and K. Rathinasamy and R. Mohan and D. Panda},
  journal={IUBMB Life},
  • P. Singh, K. Rathinasamy, +1 author D. Panda
  • Published 2008
  • Biology, Medicine
  • IUBMB Life
  • Microtubules, composed of αβ tubulin dimers, are dynamic polymers of eukaryotic cells. They play important roles in various cellular functions including mitosis. Microtubules exhibit differential dynamic behaviors during different phases of the cell cycle. Inhibition of the microtubule assembly dynamics causes cell cycle arrest leading to apoptosis; thus, qualifying them as important drug targets for treating several diseases including cancer, neuronal, fungal, and parasitic diseases. Although… CONTINUE READING
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