Microtubule assembly dynamics: An attractive target for anticancer drugs

@article{Singh2008MicrotubuleAD,
  title={Microtubule assembly dynamics: An attractive target for anticancer drugs},
  author={Parminder Singh and K. Rathinasamy and Renu Mohan and D. Panda},
  journal={IUBMB Life},
  year={2008},
  volume={60}
}
Microtubules, composed of αβ tubulin dimers, are dynamic polymers of eukaryotic cells. They play important roles in various cellular functions including mitosis. Microtubules exhibit differential dynamic behaviors during different phases of the cell cycle. Inhibition of the microtubule assembly dynamics causes cell cycle arrest leading to apoptosis; thus, qualifying them as important drug targets for treating several diseases including cancer, neuronal, fungal, and parasitic diseases. Although… Expand
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