Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials.
@article{Pampaloni2008MicrotubuleAI, title={Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials.}, author={Francesco Pampaloni and E L Florin}, journal={Trends in biotechnology}, year={2008}, volume={26 6}, pages={ 302-10 } }
127 Citations
Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization.
- BiologyACS nano
- 2012
This work demonstrates in vivo how multiwalled carbon nanotubes (MWCNTs) interact with microtubules in human cancer cells (HeLa) blocking mitosis and leading to cell death by apoptosis and suggests that, inside the cells, MWCNTs display microtubule biomimetic properties.
Nanotube interactions with microtubules: implications for cancer medicine.
- BiologyNanomedicine
- 2014
The potential use of carbon nanotubes in cancer medicine is reviewed to support the idea that CNTs represent a ground-breaking type of synthetic microtubule-stabilizing agents that could play a pivotal role in future cancer treatments in combination to traditional antineoplastic drugs.
All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin.
- BiologyACS nano
- 2020
Books focusing on how microtubules act as nanowires capable of intracellular ionic transport, charge storage, and ionic signal amplification are reviewed, illustrating how these biopolymers attenuate ionic movement in response to electrical stimuli.
Microtubule-Inspired Functionalization of Carbon Nanotubes: A Biomimetic Carrier Design
- Biology, ChemistrybioRxiv
- 2022
Specific mutations on the wildtype peptides are proposed to refine their hydrophobicity, eliminate unfavorable inter-peptides electrostatic interactions or the spatial hindrance at certain regions, to enhance their conformational steadiness and exposure to the tube surface.
Biomimetic and Bioinspired Self-Assembled Peptide Nanostructures
- Biology, Chemistry
- 2012
A comprehensive overview of the most recent advances in the design, synthesis, and application of biomimetic building blocks with biological functionalities, which are obtained by chemical functionalization as well as genetic engineering of natural peptides are provided.
Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment
- BiologyJournal of Nanobiotechnology
- 2020
The potential application of these synthetic microtubule-stabilizing agents as synergetic agents to boost the effect of classical chemotherapy that includes spindle poisons or DNA interfering agents is discussed.
An improved electrical model of microtubule as biomolecular nonlinear transmission line
- Biology, Engineering2014 29th International Conference on Microelectronics Proceedings - MIEL 2014
- 2014
An improved electrical model of microtubule as biomolecular nonlinear transmission line is established and the basic nanoscale electric elements of model are described and the corresponding parameters are estimated, stressing the particular importance of tubulin C-termini.
The Effect of Defects and Surface Modification on Biomolecular Assembly and Transport
- Materials Science, Biology
- 2019
The effects of large scale “defective” segments (i.e. non-biotinylated MTs) on active assembly of nanocomposite spools are described and the preferential removal of the defective portions from spools during assembly is demonstrated to overcome structurally induced strain in regions that lack biotin-streptavidin bonds.
Carbon nanotubes display intrinsic anticancer properties
- Biology
- 2014
Findings support the idea that CNTs represent a ground-breaking type of synthetic microtubule-stabilizing agents that could play a pivotal role in future cancer treatments in combination to traditional antineoplastic drugs.
The Cytoskeleton as a Nanoscale Information Processor: Electrical Properties and an Actin-Microtubule Network Model
- Biology
- 2009
An information-processing model based on cytoskeletal networks is described, which may underlie certain types of learning and memory.
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