Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials.

  title={Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials.},
  author={Francesco Pampaloni and E L Florin},
  journal={Trends in biotechnology},
  volume={26 6},

Figures and Tables from this paper

Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization.

This work demonstrates in vivo how multiwalled carbon nanotubes (MWCNTs) interact with microtubules in human cancer cells (HeLa) blocking mitosis and leading to cell death by apoptosis and suggests that, inside the cells, MWCNTs display microtubule biomimetic properties.

Nanotube interactions with microtubules: implications for cancer medicine.

The potential use of carbon nanotubes in cancer medicine is reviewed to support the idea that CNTs represent a ground-breaking type of synthetic microtubule-stabilizing agents that could play a pivotal role in future cancer treatments in combination to traditional antineoplastic drugs.

All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin.

Books focusing on how microtubules act as nanowires capable of intracellular ionic transport, charge storage, and ionic signal amplification are reviewed, illustrating how these biopolymers attenuate ionic movement in response to electrical stimuli.

Microtubule-Inspired Functionalization of Carbon Nanotubes: A Biomimetic Carrier Design

Specific mutations on the wildtype peptides are proposed to refine their hydrophobicity, eliminate unfavorable inter-peptides electrostatic interactions or the spatial hindrance at certain regions, to enhance their conformational steadiness and exposure to the tube surface.

Biomimetic and Bioinspired Self-Assembled Peptide Nanostructures

A comprehensive overview of the most recent advances in the design, synthesis, and application of biomimetic building blocks with biological functionalities, which are obtained by chemical functionalization as well as genetic engineering of natural peptides are provided.

Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment

The potential application of these synthetic microtubule-stabilizing agents as synergetic agents to boost the effect of classical chemotherapy that includes spindle poisons or DNA interfering agents is discussed.

An improved electrical model of microtubule as biomolecular nonlinear transmission line

  • D. SekulicM. Sataric
  • Biology, Engineering
    2014 29th International Conference on Microelectronics Proceedings - MIEL 2014
  • 2014
An improved electrical model of microtubule as biomolecular nonlinear transmission line is established and the basic nanoscale electric elements of model are described and the corresponding parameters are estimated, stressing the particular importance of tubulin C-termini.

The Effect of Defects and Surface Modification on Biomolecular Assembly and Transport

The effects of large scale “defective” segments (i.e. non-biotinylated MTs) on active assembly of nanocomposite spools are described and the preferential removal of the defective portions from spools during assembly is demonstrated to overcome structurally induced strain in regions that lack biotin-streptavidin bonds.

Carbon nanotubes display intrinsic anticancer properties

Findings support the idea that CNTs represent a ground-breaking type of synthetic microtubule-stabilizing agents that could play a pivotal role in future cancer treatments in combination to traditional antineoplastic drugs.

The Cytoskeleton as a Nanoscale Information Processor: Electrical Properties and an Actin-Microtubule Network Model

An information-processing model based on cytoskeletal networks is described, which may underlie certain types of learning and memory.



Reversible switching of microtubule motility using thermoresponsive polymer surfaces.

We report a novel approach for the dynamic control of gliding microtubule motility by external stimuli. Our approach is based on the fabrication of a composite surface where functional kinesin

Silver Nanoparticle and Nanowire Formation by Microtubule Templates

The synthesis of increasingly miniaturized structures using alternative techniques is strongly motivated by future applications in areas such as nanoelectronics. Highly ordered protein assemblies of

Molecular biomimetics: nanotechnology through biology

This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds.

The physical basis of microtubule structure and stability

Through the combination of an atomically detailed model for a microtubule and large‐scale computational techniques for computing electrostatic interactions, the observed microtubules structure is explained and it is determined that B lattice is the most favorable configuration.

Controlled assembly of carbon nanotubes by designed amphiphilic Peptide helices.

The data presented herein show that the peptide folds into an amphiphilic alpha-helix in the presence of carbon nanotubes and disperses them in aqueous solution by noncovalent interactions with the nanotube surface.

Microtubule bending and breaking in living fibroblast cells.

It is shown that the rate of microtubule breaking in fibroblast cells increases approximately 40-fold as the elastic energy stored in curved microtubules increases to > approximately 1 kT/tubulin dimer, suggesting a physiologically important, micro tubule-based mechanism for mechanochemical information processing in the cell.

Nanotechnology: Carbon nanotubes with DNA recognition

This work unifies single-walled carbon nanotubes with the specific molecular-recognition features of DNA by coupling SWNTs to peptide nucleic acid (PNA, an uncharged DNA analogue) and hybridizing these macromolecular wires with complementary DNA.

Toward the development of peptide nanofilaments and nanoropes as smart materials.

The design and characterization of a helical peptide is shown, which uses phased hydrophobic interactions to drive assembly into nanofilaments and fibrils ("nanoropes") and circumvents problems of uncontrolled self-assembly seen in previous approaches that used electrostatics as a mode for self- assembly.

Preparation and characterization of individual peptide-wrapped single-walled carbon nanotubes.

Evidence is presented that atomic force microscopy can isolate individual peptide-wrapped SWNTs, possibly connected end-to-end into long fibrillar structures, using an amphiphilic alpha-helical peptide, termed nano-1.

Mechanochemical model of microtubule structure and self-assembly kinetics.

The model recapitulates three-dimensional tip structures and rates of assembly and disassembly for microtubules grown under standard conditions, and it is proposed that taxol may stabilize microtubule growth by reducing flexural rigidity and partial uncapping of the tubulin-GTP cap provides a possible mechanism for microTube pause events.