Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.

  • Thomas Timm, Jens Peter von Kries, +3 authors Eva-Maria Mandelkow
  • Published 2011 in The Journal of biological chemistry
  • DOI:10.1074/jbc.M111.257865
Protein kinases of the microtubule affinity regulating kinase (MARK)/Par-1 family play important roles in the establishment of cellular polarity, cell cycle control, and intracellular signal transduction. Disturbance of their function is linked to cancer and brain diseases, e.g. lissencephaly and Alzheimer disease. To understand the biological role of MARK… (More)