Microtubule-active agents modify nitric oxide production in pulmonary artery endothelial cells.

@article{Su2002MicrotubuleactiveAM,
  title={Microtubule-active agents modify nitric oxide production in pulmonary artery endothelial cells.},
  author={Yunchao Su and Sergei I Zharikov and Edward R. Block},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 6},
  pages={L1183-9}
}
The effects of specific microtubule-active agents on nitric oxide (NO) production were examined in pulmonary artery endothelial cells (PAEC). PAEC were incubated with taxol, which stabilizes microtubules, or nocodazole, which disrupts microtubules, or both for 2-4 h. We then examined NO production, endothelial NO synthase (eNOS) activity, and eNOS association with heat shock protein (HSP) 90. Incubation of PAEC with taxol (15 microM) for 2-4 h resulted in an increase in NO production, eNOS… CONTINUE READING

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