Microtubule-active agents mimic lipopolysaccharides in priming macrophages for enhanced arachidonic acid metabolism.

@article{Veis1996MicrotubuleactiveAM,
  title={Microtubule-active agents mimic lipopolysaccharides in priming macrophages for enhanced arachidonic acid metabolism.},
  author={N Veis and Antony Rosen and Alan Aderem},
  journal={Journal of inflammation},
  year={1996},
  volume={46 2},
  pages={106-13}
}
Macrophages play a crucial role in inflammation and host defense, in part, by secreting metabolites of arachidonic acid (20:4). Bacterial lipopolysaccharides (LPS) are poor agonists of the 20:4 cascade, but do have the capacity to prime macrophages for greatly increased 20:4 metabolism upon subsequent stimulation with activators of protein kinase C (PKC… CONTINUE READING