Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations

@article{Weisenberg1972MicrotubuleFI,
  title={Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations},
  author={Richard C. Weisenberg},
  journal={Science},
  year={1972},
  volume={177},
  pages={1104 - 1105}
}
  • R. Weisenberg
  • Published 22 September 1972
  • Chemistry, Medicine
  • Science
Isolated rat brain tubulin can be repolymerized in vitro in solutions containing adenosine triphosphate or guanosine triphosphate, magnesium ions, and a good calcium chelator. The extreme sensitivity of tubulin to calcium ions explains the failure of previous efforts to obtain polymerization and suggests a possible mechanism for regulation of microtubule polymerization in vivo. 
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