Microtubule Dynamics Are Necessary for Src Family Kinase-Dependent Growth Cone Steering

@article{Suter2004MicrotubuleDA,
  title={Microtubule Dynamics Are Necessary for Src Family Kinase-Dependent Growth Cone Steering},
  author={Daniel M Suter and Andrew W. Schaefer and Paul Forscher},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1194-1199}
}
Dynamic microtubules explore the peripheral (P) growth cone domain using F actin bundles as polymerization guides. Microtubule dynamics are necessary for growth cone guidance; however, mechanisms of microtubule reorganization during growth cone turning are not well understood. Here, we address these issues by analyzing growth cone steering events in vitro, evoked by beads derivatized with the Ig superfamily cell adhesion protein apCAM. Pharmacological inhibition of microtubule assembly with low… CONTINUE READING