Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells

@article{Gilbert1991MicrotubularOA,
  title={Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells},
  author={Teresa L. Gilbert and Andr{\'e} Le Bivic and Andrea Quaroni and Enrique Rodr{\'i}guez-Boulan},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={113},
  pages={275 - 288}
}
We characterized the three-dimensional organization of microtubules in the human intestinal epithelial cell line Caco-2 by laser scanning confocal microscopy. Microtubules formed a dense network approximately 4-microns thick parallel to the cell surface in the apical pole and a loose network 1-micron thick in the basal pole. Between the apical and the basal bundles, microtubules run parallel to the major cell axis, concentrated in the vicinity of the lateral membrane. Colchicine treatment for 4… CONTINUE READING

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Role of microtubules in polarized delivery of apical membrane proteins to be the brush border of the intestinal epithelium

  • C. Achier, D. Filmer, C. Metre, D. Drenckhahn
  • J. Cell Biol
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