Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseases.

@article{Carson1994MicrotubularDA,
  title={Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseases.},
  author={Johnny L. Carson and Albert M Collier and Gerald W. Fernald and Susan C. Hu},
  journal={Ultrastructural pathology},
  year={1994},
  volume={18 3},
  pages={327-32}
}
A critical relationship exists between ordered ciliary ultrastructure and optimal mucociliary clearance in the respiratory airways. Structurally defective cilia derived from heritable syndromes or from epithelial cell injury may promote or exacerbate chronic disease processes. A lesion of airway epithelial cilia characterized by microtubular discontinuities and previously associated with primary ciliary dyskinesia (PCD) has been documented in other forms of chronic airways diseases, including… CONTINUE READING