Microsynthesis and gas chromatography/electron ionization mass spectrometric and tandem mass spectrometric analysis of cyclic alkylphosphonates for verification of the Chemical Weapons Convention.

Abstract

We describe the microsynthesis and gas chromatography/mass spectrometric (GC/MS) analysis of cyclic alkylphosphonates (CAPs), which are included in schedule 2B4 chemicals in the Chemical Weapons Convention (CWC). The reported microsynthesis is efficient in comparison with traditional synthesis. GC/MS and GC/tandem mass spectrometric (MS/MS) analysis of a variety of CAPs revealed that their fragmentations were dominated by alpha-cleavages, alkene eliminations and hydrogen rearrangements. Based on the obtained mass spectra and precursor and product ion analysis of five-, six- and seven-membered cyclic alkylphosphonates, the proposed fragmentation routes rationalize most of the characteristic ions.

DOI: 10.1002/rcm.3644

Cite this paper

@article{Dubey2008MicrosynthesisAG, title={Microsynthesis and gas chromatography/electron ionization mass spectrometric and tandem mass spectrometric analysis of cyclic alkylphosphonates for verification of the Chemical Weapons Convention.}, author={Devendra Kumar Dubey and Deepak Pardasani and Pankaj K. Kanaujia and Vijay K Tak and Hemendra K Gupta}, journal={Rapid communications in mass spectrometry : RCM}, year={2008}, volume={22 16}, pages={2526-32} }