Microstructure and release characteristics of the minipellet, a collagen-based drug delivery system for controlled release of protein drugs.

@article{Maeda1999MicrostructureAR,
  title={Microstructure and release characteristics of the minipellet, a collagen-based drug delivery system for controlled release of protein drugs.},
  author={Masashi Maeda and Satoru Tani and Akihiko Sano and Keiji Fujioka},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1999},
  volume={62 3},
  pages={313-24}
}
We have developed the minipellet, a matrix-type system for the sustained delivery of protein drugs using collagen as a biodegradable drug carrier. In this study, we analyzed the microstructure and release profile of the minipellet containing human serum albumin (HSA) as a model drug.The findings suggest that the minipellet has a structure in which collagen fibers are strongly oriented in the direction of extrusion from the nozzle in the molding process of the minipellet, and that HSA exists as… CONTINUE READING