Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.

@article{Makki2008MicrostructuralAO,
  title={Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.},
  author={Malek Makki and Michael E. Behen and Arpi Bhatt and Benjamin J. Wilson and Harry T. Chugani},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2008},
  volume={23 16},
  pages={2349-56}
}
We applied diffusion-tensor MRI (DT-MRI) to investigate directly the water diffusivity within subcortical gray matter structures comprising the fronto-striato-thalamic (FST) circuit, which is implicated in the pathophysiology of Tourette syndrome (TS). We investigated the structural integrity of basal ganglia and thalamus in 23 children with TS and 35 age-matched healthy controls (NC), and examined the association of DT-MRI measures to tic severity and comorbid symptoms. We measured parallel… CONTINUE READING

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