Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins.

  title={Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins.},
  author={Ana Grenha and Carmen Remu{\~n}{\'a}n-L{\'o}pez and Edison Luis Santana Carvalho and Bego{\~n}a Seijo},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  volume={69 1},
Chitosan/tripolyphosphate nanoparticles have already been demonstrated to promote peptide absorption through several mucosal surfaces. We have recently developed a new drug delivery system consisting of complexes formed between preformed chitosan/tripolyphosphate nanoparticles and phospholipids, named as lipid/chitosan nanoparticles (L/CS-NP) complexes. The aim of this work was to microencapsulate these protein-loaded L/CS-NP complexes by spray-drying, using mannitol as excipient to produce… CONTINUE READING
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