Microspheres as floating drug-delivery systems to increase gastric retention of drugs.

@article{Soppimath2001MicrospheresAF,
  title={Microspheres as floating drug-delivery systems to increase gastric retention of drugs.},
  author={Kumaresh S Soppimath and Ajaykumar Kulkarni and Walter E. Rudzinski and Tejraj M. Aminabhavi},
  journal={Drug metabolism reviews},
  year={2001},
  volume={33 2},
  pages={149-60}
}
Gastric emptying is a complex process, which is highly variable and makes in vivo performance of the drug-delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 h. The floating or hydrodynamically controlled drug-delivery systems are useful in such applications. The present review addresses briefly the physiology of the gastric emptying process with respect to floating drug-delivery… CONTINUE READING

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