Microsphere-based scaffolds encapsulating tricalcium phosphate and hydroxyapatite for bone regeneration

@article{Gupta2016MicrospherebasedSE,
  title={Microsphere-based scaffolds encapsulating tricalcium phosphate and hydroxyapatite for bone regeneration},
  author={Vineet Gupta and Dina V. Lyne and Marilyn Barragan and Cory J Berkland and Michael Scott Detamore},
  journal={Journal of Materials Science: Materials in Medicine},
  year={2016},
  volume={27},
  pages={1-17}
}
Bioceramic mixtures of tricalcium phosphate (TCP) and hydroxyapatite (HAp) are widely used for bone regeneration because of their excellent cytocompatibility, osteoconduction, and osteoinduction. Therefore, we hypothesized that incorporation of a mixture of TCP and HAp in microsphere-based scaffolds would enhance osteogenesis of rat bone marrow stromal cells (rBMSCs) compared to a positive control of scaffolds with encapsulated bone-morphogenic protein-2 (BMP-2). Poly(d,l-lactic-co-glycolic… CONTINUE READING
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