Microsomal protein synthesis inhibition: an early manifestation of gentamicin nephrotoxicity.

@article{Bennett1988MicrosomalPS,
  title={Microsomal protein synthesis inhibition: an early manifestation of gentamicin nephrotoxicity.},
  author={W. M. Bennett and Leena Mela-Riker and Donald C. Houghton and David N. Gilbert and W. C. Buss},
  journal={The American journal of physiology},
  year={1988},
  volume={255 2 Pt 2},
  pages={F265-9}
}
Aminoglycoside antibiotics achieve bacterial killing by binding to bacterial ribosomes and inhibiting protein synthesis. To examine whether similar mechanisms could be present in renal tubular cells prior to the onset of overt proximal tubular necrosis due to these drugs, we isolated microsomes from Fischer rats given 20 mg/kg gentamicin every 12 h subcutaneously for 2 days and from vehicle-injected controls. Concomitant studies of renal structure, function, and mitochondrial respiration were… CONTINUE READING
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