Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.

@article{IkedaMatsuo2006MicrosomalPE,
  title={Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.},
  author={Yuri Ikeda-Matsuo and Azusa Ota and Tetsuya Fukada and Satoshi Uematsu and Shizuo Akira and Yasuharu Sasaki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 31},
  pages={11790-5}
}
Although augmented prostaglandin E(2) (PGE(2)) synthesis and accumulation have been demonstrated in the lesion sites of rodent transient focal ischemia models, the role of PGE(2) in neuronal survival has been controversial, showing both protective and toxic effects. Here we demonstrate the induction of microsomal PGE synthase 1 (mPGES-1), an inducible terminal enzyme for PGE(2) synthesis, in neurons, microglia, and endothelial cells in the cerebral cortex after transient focal ischemia. In… CONTINUE READING
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