Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

@inproceedings{Kamei2009MicrosomalPE,
  title={Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis},
  author={Daisuke Kamei and Makoto Murakami and Yuka Sasaki and Yoshihito Nakatani and Masataka C Majima and Yukio Ishikawa and Toshiharu Ishii and Satoshi Uematsu and Shizuo Akira and Shuntaro Hara and Ichiro Kudo},
  booktitle={The Biochemical journal},
  year={2009}
}
mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclo-oxygenase)-2 in the PGE2 (prostaglandin E2)-biosynthesis pathway. Although COX-2-derived PGE2 is known to play a role in the development of various tumours, the involvement of mPGES-1 in carcinogenesis has not yet been fully understood. In the present study, we used LLC (Lewis lung carcinoma) cells with mPGES-1 knockdown or overexpression, as well as mPGES-1-deficient mice to… CONTINUE READING

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