Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

@article{Hanaka2009MicrosomalPE,
  title={Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.},
  author={Hiromi Hanaka and Sven-Christian Pawelzik and John Inge Johnsen and M Zorica Rakonjac and Kan Terawaki and Agnes Rasmuson and Baldur Sveinbj{\"o}rnsson and Martin C. Schumacher and Mats H{\'a}mberg and Bengt Samuelsson and P. -J. Jakobsson and Per Kogner and Olof R{\aa}dmark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={18757-62}
}
There is strong evidence for a role of prostaglandin E(2) (PGE(2)) in cancer cell proliferation and tumor development. In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1). The human prostate cancer cell line DU145 expressed high amounts of MPGES-1 in a constitutive manner. MPGES-1 expression also was detectable in human prostate cancer tissues, where it appeared more abundant compared… CONTINUE READING
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