• Corpus ID: 27522062

Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride.

@article{Kornbrust1980MicrosomalLP,
  title={Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride.},
  author={Douglas J. Kornbrust and Richard D. Mavis},
  journal={Molecular pharmacology},
  year={1980},
  volume={17 3},
  pages={
          408-14
        }
}
Carbon tetrachloride initiated lipid peroxidation in isolated rat liver microsomes in the absence of free metal ions. In contrast to the nonenzymatic process stimulated by ferrous iron, CCl 4 -induced peroxidation showed an absolute requirement for NADPH and appeared dependent on the integrity of cytochrome P -450 as reflected by measurement of aminopyrine demethylase and aniline hydroxylase activities. The peroxidation subsided after only 10% of the total peroxidizable polyunsaturated fatty… 
Glutathione peroxidase and reactive oxygen species in TCDD-induced lipid peroxidation.
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Based on the use of scavengers of reactive oxygen species, lipid peroxidation by hepatic microsomes from both control and TCDD-treated rats appears to be due primarily to H2O2, while results indicate that superoxide, hydroxyl radical and singlet oxygen are also involved.
Destruction of microsomal calcium pump activity: a possible secondary mechanism in BrCCl3 and CCl4 liver cell injury.
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It is shown that the capacity of liver microsomes to sequester Ca2+ was severely depressed 30 min after CC14 administration to rats, and that this effect is already manifested within 3 min afterCC14 administration, by which time peroxidative decomposition of microsomal lipids can be detected.
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Inactivation of transforming activity of plasmid DNA by lipid peroxidation.
  • S. Akasaka
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1986
Pathological mechanisms in carbon tetrachloride hepatotoxicity.
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