• Corpus ID: 27522062

Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride.

  title={Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride.},
  author={Douglas J. Kornbrust and Richard D. Mavis},
  journal={Molecular pharmacology},
  volume={17 3},
Carbon tetrachloride initiated lipid peroxidation in isolated rat liver microsomes in the absence of free metal ions. In contrast to the nonenzymatic process stimulated by ferrous iron, CCl 4 -induced peroxidation showed an absolute requirement for NADPH and appeared dependent on the integrity of cytochrome P -450 as reflected by measurement of aminopyrine demethylase and aniline hydroxylase activities. The peroxidation subsided after only 10% of the total peroxidizable polyunsaturated fatty… 
Glutathione peroxidase and reactive oxygen species in TCDD-induced lipid peroxidation.
Based on the use of scavengers of reactive oxygen species, lipid peroxidation by hepatic microsomes from both control and TCDD-treated rats appears to be due primarily to H2O2, while results indicate that superoxide, hydroxyl radical and singlet oxygen are also involved.
Destruction of microsomal calcium pump activity: a possible secondary mechanism in BrCCl3 and CCl4 liver cell injury.
It is shown that the capacity of liver microsomes to sequester Ca2+ was severely depressed 30 min after CC14 administration to rats, and that this effect is already manifested within 3 min afterCC14 administration, by which time peroxidative decomposition of microsomal lipids can be detected.
The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo.
Inactivation of transforming activity of plasmid DNA by lipid peroxidation.
  • S. Akasaka
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1986
Pathological mechanisms in carbon tetrachloride hepatotoxicity.