Microsomal lipid peroxidation.

@article{Buege1978MicrosomalLP,
  title={Microsomal lipid peroxidation.},
  author={J. A. Buege and Steven D. Aust},
  journal={Methods in enzymology},
  year={1978},
  volume={52},
  pages={
          302-10
        }
}
Phospholipase A2 dependent release of fatty acids from peroxidized membranes.
  • A. Sevanian, E. Kim
  • Chemistry, Biology
    Journal of free radicals in biology & medicine
  • 1985
Lipid Peroxidation of Microsomal Membranes as the Mechanism of 4-Aminopyrazolopyrimidine-Induced Cell Injury in the Rat Liver
TLDR
Findings strongly suggest that the enzymatic reduction of Fe3+-ADP-4-APP complexes by NADPH cytochrome c reductase significantly promoted lipid peroxidation in microsomal phospholipid membranes, and was probably mediated by an active iron-oxygen complex.
Cytochrome P-450 Interaction with Arachidonic Acid Hydroperoxides: Role in Lipid Peroxidation
TLDR
The results indicate that microsomal cytochrome P-450 may play a role in the transformation of lipid hydroperoxides (such as those produced by the irradiation of membranes) to products of lipid peroxidation.
Hepatic aldehyde dehydrogenases and lipid peroxidation
Microsomal lipid peroxidation: Effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase
TLDR
The role of vitamin E in the protection against iron dependent lipid peroxidation was studied in rat liver microsomes and Triton-dispersed microsomal lipid micelles and the rationale of this cooperation is discussed on the basis of the hydroperoxyl radical scavenging capacity of Vitamin E and the reduction of membrane hydroper oxides by PHGPX.
Oxidation-dependent changes in the stability and permeability of lipid bilayers.
TLDR
Findings indicate that accumulation of lipid peroxide within lipid bilayers is not responsible for the permeability increase that is often observed in biomembranes exposed to oxidative stresses.
...
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References

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Effects of lipid peroxidation on membrane-bound enzymes of the endoplasmic reticulum.
  • E. Wills
  • Biology, Chemistry
    The Biochemical journal
  • 1971
TLDR
It is concluded that Lipid peroxidation, by controlling membrane integrity, may exert a regulating effect on the oxidative metabolism and carbohydrate metabolism of the endoplasmic reticulum in vivo.
The mechanism of liver microsomal lipid peroxidation.
Lipid peroxide formation in microsomes. General considerations.
  • E. Wills
  • Biology, Chemistry
    The Biochemical journal
  • 1969
TLDR
It is considered that lipid peroxide formation occurs as a result of the operation of the microsomal electron-transport chain switching from hydroxylation to oxidize unsaturated lipids of the endoplasmic reticulum.
...
...