Microsomal lipid peroxidation.

@article{Buege1978MicrosomalLP,
  title={Microsomal lipid peroxidation.},
  author={J. A. Buege and Steven D. Aust},
  journal={Methods in enzymology},
  year={1978},
  volume={52},
  pages={
          302-10
        }
}
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Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions.
  • Á. Catala
  • Biology, Chemistry
    Chemistry and physics of lipids
  • 2009
Phospholipase A2 dependent release of fatty acids from peroxidized membranes.
  • A. Sevanian, E. Kim
  • Chemistry, Biology
    Journal of free radicals in biology & medicine
  • 1985
Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences.
Lipid Peroxidation of Microsomal Membranes as the Mechanism of 4-Aminopyrazolopyrimidine-Induced Cell Injury in the Rat Liver
TLDR
Findings strongly suggest that the enzymatic reduction of Fe3+-ADP-4-APP complexes by NADPH cytochrome c reductase significantly promoted lipid peroxidation in microsomal phospholipid membranes, and was probably mediated by an active iron-oxygen complex.
Cytochrome P-450 Interaction with Arachidonic Acid Hydroperoxides: Role in Lipid Peroxidation
TLDR
The results indicate that microsomal cytochrome P-450 may play a role in the transformation of lipid hydroperoxides (such as those produced by the irradiation of membranes) to products of lipid peroxidation.
Hepatic aldehyde dehydrogenases and lipid peroxidation
Microsomal lipid peroxidation: Effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase
TLDR
The role of vitamin E in the protection against iron dependent lipid peroxidation was studied in rat liver microsomes and Triton-dispersed microsomal lipid micelles and the rationale of this cooperation is discussed on the basis of the hydroperoxyl radical scavenging capacity of Vitamin E and the reduction of membrane hydroper oxides by PHGPX.
Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis.
Lipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride.
Oxidation-dependent changes in the stability and permeability of lipid bilayers.
TLDR
Findings indicate that accumulation of lipid peroxide within lipid bilayers is not responsible for the permeability increase that is often observed in biomembranes exposed to oxidative stresses.
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References

SHOWING 1-10 OF 37 REFERENCES
Lactoperoxidase-catalyzed lipid peroxidation of microsomal and artificial membranes.
Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. 3. Transient formation of phospholipid peroxides.
  • B. Tam, P. McCay
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1970
Effects of lipid peroxidation on membrane-bound enzymes of the endoplasmic reticulum.
  • E. Wills
  • Biology, Chemistry
    The Biochemical journal
  • 1971
TLDR
It is concluded that Lipid peroxidation, by controlling membrane integrity, may exert a regulating effect on the oxidative metabolism and carbohydrate metabolism of the endoplasmic reticulum in vivo.
The mechanism of liver microsomal lipid peroxidation.
Lipid peroxide formation in microsomes. General considerations.
  • E. Wills
  • Biology, Chemistry
    The Biochemical journal
  • 1969
TLDR
It is considered that lipid peroxide formation occurs as a result of the operation of the microsomal electron-transport chain switching from hydroxylation to oxidize unsaturated lipids of the endoplasmic reticulum.
Lipid oxidation in biological membranes. II. Kinetics and mechanism of lipid oxidation in submitochondrial particles.
Lipid oxidation in biological membranes. I. Lipid oxidation in submitochondrial particles and microsomes induced by chaotropic agents.
Lipid oxidation in biological membranes. Electron transfer proteins as initiators of lipid autoxidation.
A possible mechanism of the generation of singlet molecular oxygen in nadph-dependent microsomal lipid peroxidation.
Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. IV. Dependence on Fe3+.
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