Microsomal incubation test of potentially hemolytic drugs for glucose-6-phosphate dehydrogenase deficiency.

@article{Bloom1983MicrosomalIT,
  title={Microsomal incubation test of potentially hemolytic drugs for glucose-6-phosphate dehydrogenase deficiency.},
  author={K E Bloom and George J. Brewer and A M Magon and N H Wetterstroem},
  journal={Clinical pharmacology and therapeutics},
  year={1983},
  volume={33 4},
  pages={403-9}
}
The in vitro metabolizing method was modified and its ability to correctly identify eight known hemolytic and nine known nonhemolytic drugs of glucose-6-phosphate (G6PD)-deficient erythrocytes was evaluated. The technique is based on inducing in vitro drug metabolism by incubation of red cells and drug with a reduced NADP-generating system in the presence of phenobarbital-induced mouse liver microsomes. Thus, this system provides a model for in vivo metabolic function. The hemolytic potential… CONTINUE READING