Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.

  title={Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.},
  author={H. Asai and Susumu Imaoka and Tamotsu Kuroki and Takeyuki Monna and Yoshihiko Funae},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={277 2},
To assess the contribution of cytochrome P450 (P450) to the microsomal ethanol oxidation system (MEOS) in humans, we examined ethanol oxidization activity in human hepatic microsomes and multiple forms of human hepatic P450s expressed in B-lymphoblastoid cells. Acetaldehyde produced by the MEOS was converted into a fluorescent derivate with cyclohexane-1,3-dione and analyzed by high-performance liquid chromatography using a fluorescence detector. The ethanol oxidation activity of seven forms of… CONTINUE READING
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