Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.

  title={Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.},
  author={Wen-Yi Huang and Nilanjan Chatterjee and Stephen J. Chanock and M. Dean and Meredith Yeager and Robert E. Schoen and Li-fang Hou and Sonja I. Berndt and Sunita Yadavalli and Christine Cole Johnson and Richard B Hayes},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={14 1},
Cigarette smoking is a risk factor for colorectal adenoma, a precursor of colorectal cancer. Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Nonsynonymous variants of EPHX1 at Tyr(113)His (exon 3) and His(139)Arg (exon 4) are associated, respectively, with low ((113)His) and high ((139)Arg) predicted activity. Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening… CONTINUE READING
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CYP1A1 (I462V) and NQO1 (P187S) polymorphisms and colorectal adenoma [abstract

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