Microsomal catalyzed N-hydroxylation of guanfacine and reduction of N-hydroxyguanfacine.

Abstract

Guanfacine 1 is a well known centrally acting alpha 2-adrenoceptor agonist with antihypertensive activity. The drug belongs to the guanidine class of compounds. The N-oxidative biotransformation of guanfacine was investigated in vitro in the presence of hepatic microsomal fractions from rabbits, pigs, and humans. The N-hydroxylated derivative N… (More)

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