Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes.

@article{Lacourciere1994MicrosomalAS,
  title={Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes.},
  author={Gerard M Lacourciere and Richard N. Armstrong},
  journal={Chemical research in toxicology},
  year={1994},
  volume={7 2},
  pages={121-4}
}
Sequence alignments of mammalian microsomal (MEH) and soluble epoxide hydrolases (SEH) with bacterial haloalkane dehalogenase (HAD) and haloacetate dehalogenase (HAcD) together with structural and functional evidence suggest that these four enzymes are structurally and mechanistically related. The catalytic mechanism of HAD and MEH have been recently shown to involve an ester intermediate formed by alkylation of an active site carboxyl group. Very pronounced sequence similarities of regions of… CONTINUE READING

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