Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.

@article{Murail2011MicrosecondSI,
  title={Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.},
  author={Samuel Murail and Bj{\"o}rn Wallner and James R. Trudell and Edward J. Bertaccini and Erik Lindahl},
  journal={Biophysical journal},
  year={2011},
  volume={100 7},
  pages={1642-50}
}
Cys-loop receptors constitute a superfamily of ion channels gated by ligands such as acetylcholine, serotonin, glycine, and γ-aminobutyric acid. All of these receptors are thought to share structural characteristics, but due to high sequence variation and limited structure availability, our knowledge about allosteric binding sites is still limited. These sites are frequent targets of anesthetic and alcohol molecules, and are of high pharmacological importance. We used molecular simulations to… CONTINUE READING

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