Microscopic viscosity and rotational diffusion of proteins in a macromolecular environment.

@article{Lavalette1999MicroscopicVA,
  title={Microscopic viscosity and rotational diffusion of proteins in a macromolecular environment.},
  author={Daniel Lavalette and Catherine T{\'e}treau and Martine Tourbez and Yves Blouquit},
  journal={Biophysical journal},
  year={1999},
  volume={76 5},
  pages={
          2744-51
        }
}
The Stokes-Einstein-Debye equation is currently used to obtain information on protein size or on local viscosity from the measurement of the rotational correlation time. However, the implicit assumptions of a continuous and homogeneous solvent do not hold either in vivo, because of the high density of macromolecules, or in vitro, where viscosity is adjusted by adding viscous cosolvents of various size. To quantify the consequence of nonhomogeneity, we have measured the rotational Brownian… CONTINUE READING
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