Microscopic spiral waves reveal positive feedback in subcellular calcium signaling.

@article{Lipp1993MicroscopicSW,
  title={Microscopic spiral waves reveal positive feedback in subcellular calcium signaling.},
  author={Peter Lipp and E. Niggli},
  journal={Biophysical journal},
  year={1993},
  volume={65 6},
  pages={2272-6}
}
The regenerative Ca(2+)-induced Ca2+ release mechanism is an important amplifier of signal transduction in diverse cells. In heart muscle cells, this mechanism contributes to the Ca2+ transient activating the mechanical contraction, but it is also believed to drive Ca2+ waves propagating within the cytosol. We investigated the subcellular Ca2+ distribution in heart muscle cells during spontaneous Ca2+ release using laser scanning confocal microscopy with a ratiometric fluorescent indicator… CONTINUE READING

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