Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy.

@article{Frey2007MicroscopicMF,
  title={Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy.},
  author={Margo T Frey and Adam J Engler and Dennis E Discher and Juliet Lee and Yu-li Wang},
  journal={Methods in cell biology},
  year={2007},
  volume={83},
  pages={47-65}
}
In conjunction with surface chemistry, the mechanical properties of cell culture substrates provide important biological cues that affect cell behavior including growth, differentiation, spreading, and migration. The phenomenon has led to the increased use of biological and synthetic polymer-based flexible substrates in cell culture studies. However, widely used methods for measuring the Young's modulus have proven difficult in the characterization of these materials, as they tend to be… CONTINUE READING

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