Microscopic insights into the NMR relaxation-based protein conformational entropy meter.

@article{Kasinath2013MicroscopicII,
  title={Microscopic insights into the NMR relaxation-based protein conformational entropy meter.},
  author={Vignesh Kasinath and Kim A. Sharp and A Joshua Wand},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 40},
  pages={15092-100}
}
Conformational entropy is a potentially important thermodynamic parameter contributing to protein function. Quantitative measures of conformational entropy are necessary for an understanding of its role but have been difficult to obtain. An empirical method that utilizes changes in conformational dynamics as a proxy for changes in conformational entropy has… CONTINUE READING