Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts.

@article{Toue2014MicroscopicIM,
  title={Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts.},
  author={Sakino Toue and Yuki Sugiura and Akiko Kubo and Mitsuyo Ohmura and Sachise Karakawa and Toshimi Mizukoshi and Junya Yoneda and Hiroshi Miyano and Yasushi Noguchi and Tsuyoshi Kobayashi and Yasuaki Kabe and Makoto Suematsu},
  journal={Proteomics},
  year={2014},
  volume={14 7-8},
  pages={810-9}
}
Imaging MS combined with CE/MS serves as a method to provide semi-quantitative and spatial information of small molecular metabolites in tissue slices. However, not all metabolites including amino acids have fully been visualized, because of low-ionization efficiency in MALDI MS. This study aimed to acquire semi-quantitative spatial information for multiple amino acids in frozen tissue slices. As a derivatization reagent, p-N,N,N-trimethylammonioanilyl N'-hydroxysuccinimidyl carbamate iodide… CONTINUE READING
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