Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin.

@article{Lacy1982MicroscopicAO,
  title={Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin.},
  author={Eric R. Lacy and Susumu Ito},
  journal={Gastroenterology},
  year={1982},
  volume={83 3},
  pages={619-25}
}
The striking reduction or absence of macroscopic necrotic lesions in rat stomachs exposed to necrotizing agents after treatment with prostaglandins has been described as "cytoprotection." However, the morphologic features of this effect have not been published. We have quantitatively evaluated in semithin sections the amount and depth of gastric mucosal damage to rat stomachs exposed to absolute ethanol with and without prostaglandin (16,16-dimethyl PGE2) pretreatment. Our findings are: (a… CONTINUE READING