Microsatellite markers for linkage and association studies.

  title={Microsatellite markers for linkage and association studies.},
  author={Jeffrey Robert Gulcher},
  journal={Cold Spring Harbor protocols},
  volume={2012 4},
During the 1990s and the first several years of this century, microsatellites or short tandem repeats were the workhorse genetic markers for hypothesis-independent studies in human genetics, facilitating genome-wide linkage studies and allelic imbalance studies. However, the rise of higher throughput and cost-effective single-nucleotide polymorphism (SNP) platforms led to the era of the SNP for genome scans. Nevertheless, it is important to note that microsatellites remain highly informative… CONTINUE READING
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