Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment.

@article{Mayer2002MicrosatelliteIO,
  title={Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment.},
  author={Frank Mayer and Ad J. M. Gillis and Winand Dinjens and J Wolter Oosterhuis and C Carsten Bokemeyer and Leendert H. J. Looijenga},
  journal={Cancer research},
  year={2002},
  volume={62 10},
  pages={2758-60}
}
Systemic cisplatin-based chemotherapy cures > or =90% of patients with metastatic germ cell tumors (GCTs). The biological basis of this exquisite chemo-sensitivity and the resistant phenotype encountered in 10-15% of patients with GCT is yet unclear. A defective mismatch repair pathway leading to microsatellite instability (MSI) has been related to resistance to cytotoxic drugs. We investigated 100 unselected GCTs and 11 clinically defined chemotherapy-resistant GCTs for MSI using 8 mono- or… CONTINUE READING
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