Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

@article{Peltomki1993MicrosatelliteII,
  title={Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.},
  author={P{\"a}ivi Peltom{\"a}ki and Ragnhild A. Lothe and Lauri A. Aaltonen and Lea Pylkk{\"a}nen and Minna Nystr{\"o}m-Lahti and Raquel Seruca and Leonor David and Ruth Holm and David Ryberg and Aage Haugen},
  journal={Cancer research},
  year={1993},
  volume={53 24},
  pages={5853-5}
}
Microsatellite instability implying multiple replication errors (RER+ phenotype) characterizes a proportion of colorectal carcinomas, particularly those from patients with the hereditary non-polyposis colorectal carcinoma syndrome. We studied the incidence of microsatellite instability in more than 500 sporadic tumors representing 6 different types of cancer. Apart from colorectal carcinoma [see the paper by Lothe et al. (Cancer Res., 53:5849-5852, 1993)] the RER+ phenotype was found in 18% (6… CONTINUE READING

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