Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides.

@article{Scarisbrick2003MicrosatelliteII,
  title={Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides.},
  author={Julia J. Scarisbrick and Tracey Jane Mitchell and Eduardo J Calonje and Guy Orchard and Robin J Russell-Jones and Sean J. Whittaker},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 4},
  pages={894-901}
}
Fifty-one mycosis fungoides samples were analyzed for microsatellite instability (MSI) using the panel of markers recommended for hereditary nonpolyposis colorectal cancer kindred and a panel we designed for cutaneous T cell lymphoma in order to compare detection rates and determine if MSI is a genome-wide phenomenon. Samples demonstrating MSI were analyzed for abnormalities of the hMLH1 gene including loss of heterozygosity, mutations, and promoter hypermethylation. MSI was detected in 16… CONTINUE READING
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