Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis.

@article{Feeley1999MicrosatelliteII,
  title={Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis.},
  author={Kenneth M Feeley and John F Fullard and Michael A. Heneghan and Terri M Smith and Michael Maher and Raymond P.J. Murphy and Thomas A. O'Gorman},
  journal={The Journal of pathology},
  year={1999},
  volume={188 1},
  pages={14-7}
}
Fifty sporadic colorectal carcinomas diagnosed in 1991 were analysed for microsatellite instability at four loci. Five of 50 (10 per cent) tumours showed replication errors (RERs) at two or more loci and were classed as RER-positive (RER+). A further five showed RERs at one locus only. A significant association (Fisher exact test) was found between RER+ tumours and location in the proximal colon, exophytic shape, size >5 cm, histological margin, lymphoid reaction, and near-diploid DNA content… CONTINUE READING

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