Microsatellite instability in multiple colorectal tumors.

  title={Microsatellite instability in multiple colorectal tumors.},
  author={Monica Pedroni and Maria Grazia Tamassia and Antonio Percesepe and Luca Roncucci and Piero Benatti and Giovanni Lanza and Roberta Gaf{\'a} and Carmela Di Gregorio and Rossella Fante and Lorena Losi and L Gallinari and Francesca Scorcioni and Fabiana Vaccina and Giuseppina Rossi and Anna Maria Cesinaro and Maurizio Ponz de Leon},
  journal={International journal of cancer},
  volume={81 1},
Tumor multiplicity is a hallmark of hereditary cancers: in the colon-rectum multiple tumors represent 5-10% of all colorectal cancer cases. A portion of these cases belongs to hereditary non-polyposis colorectal cancer (HNPCC), a genetic cancer syndrome due to mismatch repair (MMR) gene mutations, phenotypically expressed as microsatellite instability (MSI); the majority of multiple tumors, however, is apparently without any family history. We analyzed 78 (38 synchronous and 40 metachronous… CONTINUE READING

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