Microsatellite instability in metastatic colorectal cancer: a review of pathology, response to chemotherapy and clinical outcome.

  • K L Yim
  • Published 2012 in Medical oncology

Abstract

Approximately 10% of colorectal carcinomas demonstrate microsatellite instability (MSI). Distinct from the majority of colorectal cancers with chromosomal instability (CIN) which harbour allelic imbalance from chromosomal polyploidy and aneuploidy, MSI tumours retain intact chromosomal numbers but contain microsatellite repeats due to deficiency in mismatch… (More)
DOI: 10.1007/s12032-011-0050-6

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