Microsatellite instability associated with primary head and neck cancers and secondary esophageal cancers.

@article{Kiriu1998MicrosatelliteIA,
  title={Microsatellite instability associated with primary head and neck cancers and secondary esophageal cancers.},
  author={Hiroshi Kiriu and Hiroshi Yokozaki and Wataru Yasui and Katsuki Ito and Eiichi Tahara},
  journal={Japanese journal of clinical oncology},
  year={1998},
  volume={28 12},
  pages={733-9}
}
BACKGROUND It is common that patients with head and neck cancers have secondary malignant neoplasm of esophageal cancer. METHODS To know the genetic background of the development of these secondary cancers, we performed microsatellite assay at six loci and immunohistochemical analysis on head and neck cancers of eight patients with esophageal cancer and on those of 19 patients without esophageal cancer. RESULTS Replication error (RER) at more than two loci was observed in two (25%) of eight… CONTINUE READING