Microsatellite instability and mutation of DNA mismatch repair genes in gliomas.

  title={Microsatellite instability and mutation of DNA mismatch repair genes in gliomas.},
  author={S Y Leung and T. L. Chan and Leung Ping Chung and Andrew Siu Chung Chan and Yiu Wah Fan and Kwan Ngai Hung and Wai Kuen Kwong and Jessica WM Ho and Siu Tsan Yuen},
  journal={The American journal of pathology},
  volume={153 4},
Microsatellite instability (MSI) has been identified in various human cancers, particularly those associated with the hereditary nonpolyposis colorectal cancer syndrome. Although gliomas have been reported in a few hereditary nonpolyposis colorectal cancer syndrome kindred, data on the incidence of MSI in gliomas are conflicting, and the nature of the mismatch repair (MMR) defect is not known. We established the incidence of MSI and the underlying MMR gene mutation in 22 patients ages 45 years… CONTINUE READING


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