Microsatellite instability and mismatch repair genes in colorectal cancer: useful tools for managing patients and counseling their relatives.

@article{Douillard2010MicrosatelliteIA,
  title={Microsatellite instability and mismatch repair genes in colorectal cancer: useful tools for managing patients and counseling their relatives.},
  author={Jean Yves Douillard},
  journal={Clinical colorectal cancer},
  year={2010},
  volume={9 4},
  pages={
          193-4
        }
}
Colorectal cancer (CRC) is diagnosed at a localized stage or regional extension in roughly 75% of patients. Most patients will be cured by surgical resection with or without adjuvant chemotherapy. Prevention and early detection have demonstrated efficacy in terms of incidence and cure rates. Colorectal cancer is a disease in which genetic basis has been hypothesized and later proven. Lynch syndrome accounts for up to 5% of all patients with CRC, and an additional 20% of patients with CRC may… CONTINUE READING
BETA