Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.

@article{Bertagnolli2011MicrosatelliteIA,
  title={Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.},
  author={Monica M. Bertagnolli and Mark S. Redston and Carolyn C. Compton and Donna Niedzwiecki and Robert J. Mayer and Richard M. Goldberg and Thomas Anthony Colacchio and Leonard B. Saltz and Robert S. Warren},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 23},
  pages={
          3153-62
        }
}
PURPOSE Colorectal cancer (CRC) develops as a result of a series of accumulated genomic changes that produce oncogene activation and tumor suppressor gene loss. These characteristics may classify CRC into subsets of distinct clinical behaviors. PATIENTS AND METHODS We studied two of these genomic defects-mismatch repair deficiency (MMR-D) and loss of heterozygosity at chromosomal location 18q (18qLOH)-in patients enrolled onto two phase III cooperative group trials for treatment of… CONTINUE READING
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