Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma.

  title={Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma.},
  author={Hirohito Momoi and Tomoo Itoh and Yuichi Nozaki and Yuko Arima and Hirohisa Okabe and Seiji Satoh and Yoshinobu Toda and Eiki Sakai and Kan-ichi Nakagawara and Peer Flemming and Masakazu Yamamoto and Yasuyuki Shimahara and Yoshio Yamaoka and Manabu Fukumoto},
  journal={Journal of hepatology},
  volume={35 2},
BACKGROUND/AIMS Intrahepatic cholangiocarcinoma (ICC) arises from intrahepatic bile duct epithelium and is the second most prevalent among primary liver cancers. The aim of this study was to clarify the mechanism of cholangiocarcinogenesis. METHODS We studied the incidence of microsatellite instability (MSI) involving eight highly polymorphic microsatellite markers and alternations of the K-ras, p53 and mdm-2 genes in human ICC tissues. Overexpression of mdm-2 oncoprotein was also… CONTINUE READING


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