Microsatellite instability and TARBP2 mutation study in upper urinary tract urothelial carcinoma.

@article{Bai2013MicrosatelliteIA,
  title={Microsatellite instability and TARBP2 mutation study in upper urinary tract urothelial carcinoma.},
  author={Shuting Bai and Amberly L Nunez and Shi Gao Wei and Amy Ziober and Yuan Yao and John E. Tomaszewski and Zhanyong Bing},
  journal={American journal of clinical pathology},
  year={2013},
  volume={139 6},
  pages={765-70}
}
Microsatellite instability (MSI) contributes to the tumorigenesis of upper urinary tract urothelial carcinomas (UUT-UCs). In this study, we first used MLH1 and MSH2 immunohistochemistry to identify patients with loss of expression of either or both of these proteins in 132 UUT-UCs. We found a total loss of MSH2 expression in 4 patients. MSI was evaluated using 5 markers in these 4 cases. All of the tumors had high MSI (MSI-H) status. Trans-activation responsive RNA-binding protein 2, an… CONTINUE READING
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